International Medical Graduates


The United States Medical Licensing Examination (USMLE®) is a three-step examination for medical licensure in the United States. This is a mandatory examination for American Medical Students, Canadian Medical Students and International Medical Graduates, prior to practicing medicine in the United States of America. The USMLE® is sponsored by the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME).

USLME Step 1

United States Medical Licensing Examination

  • USMLE Step 1 assesses whether you understand and can apply important concepts of the sciences basic to the practice of medicine.
  • USMLE Step 1 Topics emphaszies principles and mechanisms underlying health, disease, and modes of therapy.
  • The USMLE Step 1 ensures mastery of not only the sciences that provide a foundation for the safe and competent practice of medicine, but also the scientific principles required for maintenance of competence through lifelong learning.
  • SYSTEM and PROCESS are the two fundamental mandates of the USMLE Step 1 Examination
  • Step 1 is a one-day examination divided into seven 60-minute blocks and administered in one 8-hour testing session.
  • The number of questions per block on a given examination form will vary, but will not exceed 40.
  • The total number of items on the overall examination form will not exceed 280.

USMLE Step 1


  • anatomy
  • behavioral sciences
  • biochemistry
  • biostatistics and epidemiology
  • microbiology
  • pathology
  • pharmacology
  • physiology

The USMLE Step 1 examination also covers content related to the following interdisciplinary areas:

  • genetics
  • aging
  • immunology
  • nutrition
  • molecular and cell biology


A 32-year-old woman with type 1 diabetes mellitus has had progressive renal failure over the past 2 years. She has not yet started dialysis. Examination shows no abnormalities. Her hemoglobin concentration is 9 g/dL, hematocrit is 28%, and mean corpuscular volume is 94 m3. A blood smear shows normochromic, normocytic cells. Which of the following is the most likely cause?

  • A. Acute blood loss
  • B. Chronic lymphocytic leukemia
  • C. Erythrocyte enzyme deficiency
  • D. Erythropoietin deficiency
  • E. Immunohemolysis
  • F. Microangiopathic hemolysis
  • G. Polycythemia vera
  • H. Sickle cell disease
  • I. Sideroblastic anemia
  • J. β-Thalassemia trait

(Answer: D)

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